Le Centre National de Référence des Infections Sexuellement Transmissibles bactériennes est coordonné par le laboratoire de Bactériologie du Pr C. Bébéar au CHU de Bordeaux
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Articles dans des revues internationales ou nationales avec comité de lecture

2025

  • Prevention and management of syphilis in pregnant and perinatal women. (2025) Olivia Anselem O, Cœur CL, Tazi A, Lachâtre M, Giber R, Caseris M, Vauloup-Fellous C, Pinquier D, Chosidow A, Driessen M, Mallart E, Saunie Ar, Bergamelli M, Hcini N, Benhaddou N, Grange P, Barbaud A, Soria A, de Cousser J-W, Coppry M, Flateau C, Cazanave C, Lesprit P, Berre RL, Dupin N, Djomkoue-Monkam C, Guinaud J, Gaudelus J, Fichter A, Parat S, Huissoud C, Kayem G, Quillacq AD, Blanc J, Dap M, Eboué F, Picone O, Garabédian C, Birgy A, Bidet P, Lecuyer H, Bébéar C, Lanotte P, Lalande V, Vuotto F, Sibiude J, Charlier C. Infectious Diseases Now. doi: https://doi.org/10.1016/j.idnow.2025.105162
  • Analysis of Treponema pallidum pallidum predicted outer membrane proteins (OMPeomes) in 21 clinical samples: variant sequences are predominantly surface-exposed. (2025) Pospíšilová P, Fedrová P, Vrbová E, Hennelly CM, Aghakhanian F, Hawley KL, Bettin EB, Davenport TC, Bruisten SM, Zondag HCA, Grange PA, Dupin N, Arora N, Noda AA, Seña AC, Caimano MJ, Salazar JC, Juliano JJ, Moody MA, Radolf JD, Parr JB, Šmajs D. mSphere. Aug 29 ;10(9) :e0021325.

2024

  • Doxycycline prophylaxis and meningococcal group B vaccine to prevent bacterial sexually transmitted infections in France (ANRS 174 DOXYVAC): a multicenter, open-label, randomized trial with a 2 x 2 factorial design. (2024) Molina JM, Bercot B, Assoumou L, Rubenstein E, Algarte-Genin M, Pialoux G, Katlama C, Surgers L, Bébéar C, Dupin N, Ouattara M, Slama L, Pavie J, Duvivier C, Loze B, Goldwirt L, Gibowski S, Ollivier M, Ghosn J, Costagliola D; ANRS 174 DOXYVAC Study Group. Lancet Infect Dis. Oct;24(10):1093-1104.
  • Early neurosyphilis with serofast state. (2024) Zayet S, Poloni S, Gendrin V, Chanal J, Dupin N, Klopfenstein T. Emerg Microbes Infect. Dec;13(1):2373305. doi: 10.1080/22221751.2024.2373305.
  • Syphilis testing in blood donors, France, 2007 to 2022. (2024) Laperche S, Sauvage C, Le Cam S, Lot F, Malard L, Gallian P, Pouchol E, Richard P, Morel P, Grange P, Tiberghien P, Benhaddou N, Dupin N. Euro Surveill. Aug;29(32):2400036. doi: 10.2807/1560-7917.ES.2024.29.32.2400036.
  • Sexually transmitted digestive tract infections: One train can hide another. (2024) Salle R, Dupin N. J Eur Acad Dermatol Venereol. 2024 Apr;38(4):629-630. doi: 10.1111/jdv.19855.
  • Treponema pallidum resistance to azithromycin in France: A nationwide retrospective study from 2010 to 2022. (2024) Salle R, Grange PA, Ollagnier G, Hembert R, Benhaddou N, Heller U, Dupin N. J Eur Acad Dermatol Venereol. Jan;38(1):e20-e21. doi: 10.1111/jdv.19399.

2023

  • Evaluation of the usefulness of routine molecular biology for the diagnosis of primary syphilis by assessing the serological status of patients with PCR-confirmed syphilitic ulcers. (2023) Hembert R, Salle R, Grange PA, Ollagnier G, Benhaddou N, Heller U, Saule J, Del Giudice P, Fouéré S, Bertolotti A, Dupin N. J Eur Acad Dermatol Venereol. Dec 22. doi: 10.1111/jdv.19761.
  • Surveillance des IST bactériennes en Médecine Générale, France métropolitaine, 2020-2022. (2023) Niaré D, Launay T, Rossignol L, Lot F, Steichen O, Dupin N, Bébéar C, Berçot B, Ndeikoundam Ngangro N, Blanchon T, Chazelle E. Bulletin Epidémiologique Hebdomadaire N° 24-25 | 12 décembre 2023 | 515
  • Comparison of molecular and serological assays on cerebrospinal fluid for the diagnosis of neurosyphilis. (2023) Salle R, Grange PA, Ollagnier G, Benhaddou N, Heller U, Dupin N. J Eur Acad Dermatol Venereol. 37:390-394.

2022

  • Secondary syphilis: An ecthyma-like syphilis case report. (2022) Ichane F, Duquenne S, Poubeau P, Dupin N, Bertolotti A. Ann Dermatol Venereol. 149:209-210
  • Use of healthcare reimbursement data to monitor bacterial sexually transmitted infection testing in France, 2006 to 2020. (2022) Viriot D, Lucas E, de Barbeyrac B, Bébéar C, Fouéré S, Dupin N, Bertolotti A, Berçot B, Cazanave C, Delmas G, Pillonel J, Lot F, Ngangro NN. Euro Surveill. Sep;27(39):2100618. 
  • Specific detection of Treponema pallidum in clinical samples: validation of a qPCR assay combining two genomic targets. (2022) Salle R, Mayslich C, Grange PA, Leducq V, Ollagnier G, Heller U, Saule J, Martinet P, Robert JL, Benhaddou N, Fouéré S, Dupin N. Sex Transm Infect. Mar;99(2):91-96. doi: 10.1136/sextrans-2021-055364.
  • Syphilis is a rare cause of erythema nodosum: a case report. (2022) Anthony N, Duquenne S, Zemali N, Foucher A, Dupin N, Bertolotti A. Infect Drug Resist. 15:307-310.

2021

  • 2020 European guideline on the management of syphilis. (2021) Janier M, Unemo M, Dupin N, Tiplica GS, Potocnik M, Patel R. J Eur Acad Dermatol Venereol. 35(3):574-588
  • High prevalence of syphilis in women, minors and precarious patients: a cross-sectional study in a Reunion Island sexually transmitted infection clinic, 2017-2020. (2021) Delfosse A, Bouscaren N, Dupin N, Jaubert J, Tran PL, Saint Pastou C, Manaquin R, Poubeau P, Gerardin P, Bertolotti A. J Eur Acad Dermatol Venereol. 35(11):2287-2292.
  • Ceftriaxone compared with benzylpenicillin in the treatment of neurosyphilis in France: a retrospective multicentre study. (2021) Bettuzzi T, Jourdes A, Robineau O, Alcaraz I, Manda V, Molina JM, Mehlen M, Cazanave C, Tattevin P, Mensi S, Terrier B, Régent A, Ghosn J, Charlier C, Martin-Blondel G, Dupin N. Lancet Infect Dis. https://doi.org/10.1016/S1473-3099(20)30857-4.
  • Azithromycin resistance in Treponema pallidum in Reunion island: a cross-sectional study. (2021) Bourgeois G, Grange P, Saint-Pastou Terrier C, Koumar Y, Manaquin R, Zemali N, Poubeau P, Dupin N, Jaubert J, Bertolotti A. Ann Dermatol Venereol. 16:S0151-9638(21)00015-6.

2020

  • European guideline on the management of syphilis. (2020)Janier M, Unemo M, Dupin N, Tiplica GS, Potočnik M, Patel R. J Eur Acad Dermatol Venereol. doi: 10.1111/jdv.16946.
  • Serological diagnosis of secondary syphilis in a Rituximab-treated patient: an emerging diagnosis challenge. (2020) Lefeuvre C, Croué A, Abgueguen P, Letzelter M, Ducancelle A, Grange P, Benhaddou N, Dupin N, Le Guillou-Guillemette H, Le Clec'h C. J Eur Acad Dermatol Venereol. doi:10.1111/jdv.17126.
  • Surveillance of antibiotic resistance genes in Treponema pallidum subspecies pallidum from patients with early syphilis in France. (2020) Sanchez A, Mayslish C, Malet I, Grange PA, Janier M, Saule J, Martinet P, Robert JL, Moulene D, Truchetet F, Pinault AL, Vermersch-Langlin A, Benhaddou N, Chanal J, Dupin N. Acta Dermatol Venereol. 100(14):adv00221.
  • Oral forms of secondary syphilis, an illustration of the pitfalls set by the great imitator. (2020) Lampros A, Seta V, Gerhardt P, Isnard C, Husson C, Dupin N. J Am Acad Dermatol. 2020 Apr 24:S0190-9622(20)30705-2.
  • Use of a multiplex assay to assess the presence of Treponema pallidum in mucocutaneous ulcerations in patients with suspected syphilis. (2020) Grange PA, Jary A, Isnard C, Burrel S, Boutolleau D, Touati A, Bébéar C, Saule J, Martinet P, Robert JL, Moulene D, Vermersch-Langlin A, Benhaddou N, Janier M, Dupin N. J Clin Microbiol. 59(2):e01994-20.

2019

  • Bacterial Sexually Transmitted Infections in France: Recent Trends and Patients' Characteristics in 2016. (2019) Ndeikoundam Ngangro N, Viriot D, Fournet N, Pioche C, De Barbeyrac B, Goubard A, Dupin N, Berçot B, Fouéré S, Alcaraz I, Ohayon M, Spenatto N, Vernay-Vaisse C, Pillonel J, Lot F; Referents for the regional offices of the French national public health agency. Euro Surveill. 24(5):1800038.
  • HIV and other STI on the grill. (2019) Dupin N. Ann Dermatol Venereol. 2019 146(12S):A3-A4.
  • Congenital syphilis: A prospective study of 22 cases diagnosed by PCR. (2019) Garel B, Grange P, Benhaddou N, Schaub B, Desbois-Nogard N, Thouvenin M, Lepoutre X, Levy R, Navarro C, Charlier C, Ndeikoundam Ngangro N, Viriot D, Dupin N. Ann Dermatol Venereol. 2019 Nov;146(11):696-703.
  • Directly sequenced genomes of contemporary strains of syphilis reveal recombination-driven diversity in genes encoding predicted surface-exposed antigens. (2019) Grillová L, Oppelt J, Mikalová L, Nováková M, Giacani L, Niesnerová A, Noda AA, Mechaly AE, Pospíšilová P, Čejková D, Grange PA, Dupin N, Strnadel R, Chen M, Denham I, Arora N, Picardeau M, Weston C, Forsyth RA, Šmajs D. Front Microbiol. 10:1691.
  • Une syphilis «précoce». (2019) Sanchez A, Del Giudice P, Peneau A, Grange P, Dupin N, Hubiche T. Ann Dermatol Venereol. https://doi.org/10.1016/j.annder.2019.10.032

2018

  • Treatment of syphilis associated cerebral vasculitis: Reappearance of an old question. (2018) Nageau A, Rodriguez-Régent C, Dion J, Dupin N, Mouthon L, Le Jeunne C, Régent A. Am J Med. 131(12):1516-1519.
  • Relevance of healthcare reimbursement data to monitor syphilis epidemic: an alternative surveillance through the national health insurance database in France, 2011-2013. (2018) Ngangro Ndeikoundam N, Viriot D, Lucas E, Boussac-Zarebska M, Lot F, Dupin N, La Ruche G. BMJ Open. 8(7):e020336.
  • Multi-locus sequence typing of Treponema pallidum subsp. pallidum present in clinical samples from France: Infecting treponemes are genetically diverse and belong to 18 allelic profiles. (2018) Pospíšilová P, Grange PA, Grillová L, Mikalová L, Martinet P, Janier M, Vermersch A, Benhaddou N, Del Giudice P, Alcaraz I, Truchetet F, Dupin N, Šmajs D. PLoS ONE. 13(7):e0201068.
  • Treatment of syphilis-associated cerebral vasculitis: reappearance of an old question. (2018) Mageau A, Rodriguez-Régent C, Dion J, Dupin N, Mouthon L, Le Jeunne C, Régent A. Am J Med. 131(12):1516-1519.

2017

  • Human Treponema pallidum 11q/j isolate belongs to subsp. endemicum but contains two loci with a sequence in TP0548 and TP0488 similar to subsp. pertenue and subsp. pallidum, respectively. (2017) Mikalova L, Strouhal M, Oppelt J, Grange PA, Janier M, Benhaddou N, Dupin N, Smajs D. PloS Negl Trop Dis. 11(3):e0005434.
  • Prognostic factors in syphilis uveitis. (2017) Hoogewoud F, Frumholtz L, Loubet P, Charlier C, Blanche P, Lebeaux D, Benhaddou N, Sedira N, Coutte L, Vanhaecke C, Launay O, Le Jeunne C, Héron E, Monnet D, Lortholary O, Sahel JA, Dupin N, Brézin A, Errera MH, Salah S, Groh M. Ophtalmol. 124:1808-1816.
  • Immune reconstitution inflammatory syndrome presenting as secondary syphilis with polymorphous erythema and knee arthritis. (2017) Brochard J, Khatchatourian L, Woaye-Hune P, Biron C, Lefebvre M, Denis-Musquer M, Grange P, Dupin N, Raffi F. J Eur Acad Dermatol Venereol. 31:e381-e382.
  • Bulletin de veille sanitaire thématique IST & VIH Réunion & Mayotte: Point sur la syphilis congénitale. (2017) Benhaddou N, Grange P, Dupin N. BVS 35:19-22.

2016

  • Isolation of Treponema DNA from necrophagous flies in a natural ecosystem. (2016) Knauf S, Raphael J, Mitjà O, Lejora IA, Chuma IS, Batamuzi EK, Keyyu JD, Fyumagwa R, Lüert S, Godornes C, Liu H, Schwarz C, Šmajs D, Grange P, Zinner D, Roos C, Lukehart SA. 16:30343-30347.
  • Treponema pallidum 11qj subtype may correspond to a Treponema pallidum endemicum strain. (2016) Grange P, Mikalova L, Gaudin C, Strouhal M, Janier M, Benhaddou N, Smajs D, Dupin N. Sex Trans Dis. 43:517-518.
  • Clinical and biological characteristics of neurosyphilis in 40 patients, and evaluation of Treponema pallidum nPCR on the CSF. (2016) Vanhaecke C, Grange P, Benhaddou N, Blanche P, Salmon D, Parize P, Lortholary O, Caumes E, Pelloux I, Epaulard O, Guinard J, Dupin N, and the Neurosyphilis network. Clin Infect Dis. 63:1180-1186.
  • Periostitis in secondary syphilis with prozone phenomenon. (2016) Mahévas T, Chanal J, Franck N, Laurent S, Avril MF, Dupin N. Rheumatology (Oxford). 55:1931.

2015

2014

  • Surveillance des infections sexuellement transmissibles bactériennes en France entre 2000 et 2012. (2014) La Ruche G, Bouyssou A, Goulard A, Dupin N, Berçot B, De Barbeyrac B, Basselier B, Delmas G, Lot F. Feuillets de Biologie. 55:31-37.

2013

  • Molecular subtyping of Treponema pallidum in Paris, France. (2013) Grange PA, Allix-Beguec C, Chanal J, Benhaddou N, Gerhardt P, Morini JP, Deleuze J, Lassau F, Janier M, Dupin N. Sex Trans Dis. 40:641-644.
  • Syphilis pustuleuse et uvéite syphilitique chez un adulte séropositif pour le VIH à un stade avancé d’immunodépression. (2013) Le Treut C, Muller P, Truchetet F, Schoeffer A, Grange P, Dupin N. Dermatol. Vénéréol. 140:S577-S578.
  • Evaluation de la biologie moléculaire dans le LCR pour le diagnostic de neurosyphilis. (2013) Vanhaecke C, Grange P, Benhaddou N, Dupin N. Dermatol. Vénéréol. 140:S578.

2012

  • Evaluation of a PCR Test for Detection of Treponema pallidum in Swabs and Blood. (2012) Grange PA, Gressier L, Dion PL, Farhi D, Benhaddou N, Gerhardt P, Morini JP, Deleuze J, Pantoja C, Bianchi A, Lassau F, Avril MF, Janier M, Dupin N. J Clin Microbiol. 50:546-552.
  • Treponema pallidum induces systemic TH17 and TH1 cytokine responses. (2012) Bernardeschi C, Grange PA, Janier M, Gressier L, Dion PL, Benhaddou N, Bianchi A, Lassau F, Avril MF, Batteux F, Dupin N. Eur J Dermatol. 22:797-798.

Ouvrages scientifiques ou chapitres d’ouvrages 

  • Treponema pallidum. (2022) Benhaddou N. Chapitre du Rémic (Référentiel en Microbiologie Médicale-verskion 7), Société Française de Microbiologie (ed).
  • Syphilis : une infection toujours d’actualité. (2021) Benhaddou N, Grange P, Dupin N. Revue Française des Laboratoires. N° 530.
  • Syphilis Congénitale (2019) Benhaddou N, Grange P, Dupin N. Revue Francophone des laboratoires février 2019 N°509 P. 60-66
  • Tréponèmes pathogènes pour l’homme. (2017) Dupin N, Grange P. n°92, ESKA
  • Benhaddou N, Grange P, Dupin N. Bulletin de veille sanitaire thématique IST & VIH Réunion & Mayotte: Point sur la syphilis congénitale. (2017) BVS 35:19-22.